GeneGuessr - Daily Protein Guessing Game
How to Play GeneGuessr
Welcome to GeneGuessr!
This is the protein of the day. Can you figure out which gene made it?
You will see spoiler bars that cover valuable hints. Tap the spoiler bar to reveal a hint underneath.
Look up your favorite gene with the search bar. Submit it as your first guess.
Feedback cards
Each of your guesses will appear as a feedback card.
The feedback bar percentage shows how close you got.
Look for highlighted properties. They match your target.
Revealing hints
It costs 1 hint to remove a spoiler bar. You get +1 hint for each guess.
When the hint is too obvious, the bar stays locked. Just try unlocking another one.
You get to make 10 guesses before the game ends. Feel free to experiment!
Protein data: UniProt
Gene nomenclature: HGNC
Gene summaries: NCBI Gene
Gene Ontology: GO Consortium
Architecture: CATH
Pathway data: Reactome
Tissue specificity: Human Protein Atlas RNA expression (tau metric)
3D structures: RCSB PDB, AlphaFold DB, SWISS-MODEL
Structure viewer: Mol* (via PDBe integration)
Origin age: Litman T & Stein WD (2019). Obtaining estimates for the ages of all the protein-coding genes and most of the ontology-identified noncoding genes of the human genome, assigned to 19 phylostrata Semin Oncol 46(1):3-9
First publication year: Zwick ME, Kraemer SA & Carter GW (2019). Dataset of frequency patterns of publications for human protein-coding genes. Data Brief 28:104770